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KMID : 0644120110240010001
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Journal of Oriental Gynecology
2011 Volume.24 No. 1 p.1 ~ p.14
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The Inhibitory Effect of Picrasmae Lignum on Inflammatory Responses
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Ryu Ik-Han
Cho Han-Baek
Kim Song-Baek
Seo Yun-Jung
Choe Chang-Min
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Abstract
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Objectives: The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Picrasmae Lignum(PL).
Methods: To evaluate the anti-inflammatory effects of PL extract, the productions of NO, PGE2 and expression of pro-inflammatory cytokine(IL-1b, IL-6 and TNF-a) were measured in LPS-induced RAW 264.7 cells. Furthermore Western blot analysis has been done to look into the inhibitory mechanisms such as MAPKs and NF-kB.
Results: PL extract down-regulated LPS-induced NO, PGE2, IL-1b, IL-6 and TNF-a productions mainly through JNK and p38 MAPK pathway and NF-kB pathway.
Conclusion: These results suggest that PL extract may be effective for the treatment of inflammatory diseases.
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KEYWORD
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Picrasmae Lignum(PL), LPS, RAW 264.7 cells, Inflammation
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